Melancholic depression is a biologically homogeneous clinical entity in which structural brain alterations have been described. Interestingly. reports of structural alterations in melancholia include volume increases in Cerebro-Spinal Fluid (CSF) spaces. However. http://www.spidertattooz.com/OPI-GelColor-The-Color-That-Keeps-On-Giving-0-5-oz-HPJ07-p22791/